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(J) RNAi of skn-1 partially suppresses the effects of 50 mM metformin, 5 μM rotenone and 100 μM rapamycin on CeACAD10 expression.
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Another review concurred with these data, but noted that individual patients have been identified who experienced significant decreases in plasma concentrations of combined OC components and who appeared to ovulate; the agents most often associated with these changes were rifampin, tetracyclines, and penicillin derivatives.

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